Robo-Spiders are large, six-legged robotic spiders that are found in the It's War chapter. They pop out of the ground and start charging at Conker; if they get too close enough to him, they explode. Robo-spiders are usually found in long pathways. At one point, a whole swarm of Robo-Spiders fill in the hall and chase after Conker. Conker can do nothing but run to the elevator. When he does, a spider nearly makes it to the doors, but the doors shut and sever its leg.
- Robo-Spiders also seem to be a parody of the Vectrocon robotic spiders from the 1984 Michael Crichton film, Runaway.
- Strangely enough, The Experiment seems to hold two robo-spiders inside it as if to be used in a case in which The Experiment were to die. Little Girl referred to them as "her little babies."
- It's unclear whether the Robo-Spiders were created by the Tediz or the SHC, although possibly they are of Tediz design because they attack Conker.